|
|
sphinganine + NADP+ <=> 3-dehydrosphinganine + NADPH + H+
|
1.1.1.102
3-dehydrosphinganine reductase
|
–
|
BMK
|
|
BRENDA:
BR29168
KEGG:
R02978
MetaCyc:
3-DEHYDROSPHINGANINE-REDUCTASE-RXN;
RXN-20505
|
|
|
|
palmitoyl-CoA + sphinganine <=> N-palmitoyldihydrocerebroside + CoA + H+
|
2.3.1.24
sphingosine N-acyltransferase
2.3.1.291
sphingoid base N-palmitoyltransferase
2.3.1.297
very-long-chain ceramide synthase
2.3.1.298
ultra-long-chain ceramide synthase
2.3.1.299
sphingoid base N-stearoyltransferase
|
–
–
–
–
–
|
B
|
|
BRENDA:
BS320739
MetaCyc:
RXN-20367
|
|
|
|
sphinganine + ATP <=> H+ + sphinganine_1-phosphate + ADP
|
2.7.1.91
sphingosine kinase
|
–
|
MK
|
|
BRENDA:
BS370403
KEGG:
R02976
MetaCyc:
SPHINGANINE-KINASE-RXN
SABIO-RK:
2830
|
|
|
|
sphinganine_1-phosphate + H2O <=> sphinganine + phosphate
|
3.1.3
3.1.3.4
phosphatidate phosphatase
|
–
–
|
MK
|
|
BRENDA:
BS391833
KEGG:
R06520
MetaCyc:
DHS-PHOSPHATASE-RXN
SABIO-RK:
6096
|
|
|
|
arachidoyl-CoA + sphinganine <=> N-arachidoylsphinganine + CoA + H+
|
2.3.1.24
sphingosine N-acyltransferase
2.3.1.297
very-long-chain ceramide synthase
2.3.1.M71
|
–
–
–
|
|
|
BRENDA:
BS448947
MetaCyc:
RXN-20370
|
|
|
|
lignoceroyl-CoA + sphinganine <=> N-lignoceroyl-D-erythro-sphingosine + CoA + H+
|
2.3.1.297
very-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS448951
MetaCyc:
RXN-20371
|
|
|
|
stearoyl-CoA + sphinganine <=> N-(stearoyl)-sphinganine + CoA + H+
|
2.3.1.24
sphingosine N-acyltransferase
2.3.1.297
very-long-chain ceramide synthase
2.3.1.299
sphingoid base N-stearoyltransferase
2.3.1.M71
|
–
–
–
–
|
|
|
BRENDA:
BS448956;
BS454653
MetaCyc:
RXN-20366
|
|
|
|
acyl-CoA + sphinganine <=> dihydroceramide + CoA + H+
|
2.3.1.24
sphingosine N-acyltransferase
2.3.1.291
sphingoid base N-palmitoyltransferase
2.3.1.297
very-long-chain ceramide synthase
|
–
–
–
|
MK
|
|
BRENDA:
BS320738;
BS449519
KEGG:
R06517
MetaCyc:
RXN-7792
|
|
|
|
dihydroceramide + H2O <=> sphinganine + fatty_acid
|
3.5.1.23
ceramidase
|
–
|
K
|
|
BRENDA:
BS413350
KEGG:
R06518
|
|
|
|
sphinganine + O2 + ferricytochrome_b5 + H+ <=> phytosphingosine + H2O + ferricytochrome_b5
|
1.14.18.5
sphingolipid C4-monooxygenase
|
–
|
MK
|
|
KEGG:
R06525
MetaCyc:
RXN3O-1380
|
|
|
|
N-palmitoyldihydrocerebroside + H2O <=> palmitate + sphinganine
|
3.5.1.23
ceramidase
|
–
|
|
|
BRENDA:
BS116233
SABIO-RK:
10301
|
|
|
|
sphinganine + FAD <=> FADH2 + sphingosine
|
1.3.99
|
–
|
|
|
KEGG:
R02979
|
|
|
|
dihydroceramide + H2O <=> sphinganine + a_carboxylate
|
3.5.1.23
ceramidase
|
–
|
M
|
|
MetaCyc:
RXN-13733
|
|
|
|
myristoyl-CoA + sphinganine <=> N-myristoyl-D-erythro-sphingosine + CoA + H+
|
2.3.1.24
sphingosine N-acyltransferase
|
–
|
|
|
MetaCyc:
RXN-20368
|
|
|
|
behenoyl-CoA + sphinganine <=> N-behenoyl-D-erythro-sphingosine + CoA + H+
|
2.3.1.297
very-long-chain ceramide synthase
|
–
|
|
|
MetaCyc:
RXN-20369
|
|
|
|
hexacosanoyl-CoA + sphinganine <=> N-hexacosanoylsphinganine + CoA + H+
|
2.3.1.297
very-long-chain ceramide synthase
|
–
|
|
|
MetaCyc:
RXN-20372
|
|
|
|
30-hydroxytriacontanoyl-CoA + sphinganine <=> N-(30-hydroxytriacontanoyl)-sphinganine + CoA + H+
|
2.3.1.298
ultra-long-chain ceramide synthase
|
–
|
M
|
|
MetaCyc:
RXN-20387
|
|
|
|
sphinganine + palmitoyl-CoA <=> N-dihydropalmitoylsphingosine + CoA
|
2.3.1.299
sphingoid base N-stearoyltransferase
|
–
|
|
|
BRENDA:
BS449863
|
|
|
|
sphinganine + palmitoyl-CoA <=> N-palmitoyl-DL-dihydrosphingosine + CoA
|
2.3.1.24
sphingosine N-acyltransferase
|
–
|
|
|
BRENDA:
BS448953
|
|
|
|
sphinganine + palmitoyl-CoA <=> N-palmitoylddihydrosphingosine + CoA
|
2.3.1.24
sphingosine N-acyltransferase
|
–
|
|
|
BRENDA:
BS448954
|
|
|
|
sphinganine + palmitoyl-CoA <=> N-palmitoyldihydrocerebroside
|
2.3.1.24
sphingosine N-acyltransferase
|
–
|
|
|
BRENDA:
BS450640
|
|
|
|
N-dodecanoyl-7-nitrobenz-2-oxa-1,3,4-diazole-D-erythro-dihydrosphingosine + H2O <=> 12-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]dodecanate + sphinganine
|
3.5.1.23
ceramidase
|
–
|
|
|
BRENDA:
BS414947
|
|
|
|
11-eicosenoyl-dihydroceramide + H2O <=> sphinganine + 11-eicosenoic_acid
|
3.5.1.23
ceramidase
|
–
|
|
|
BRENDA:
BS413847
|
|
|
|
dotriacontanoyl-CoA + sphinganine <=> dotriacontanoyl-ceramide + CoA
|
2.3.1.298
ultra-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS449880
|
|
|
|
sphinganine + hexacosanoyl-CoA <=> N-cerotoyl-D-sphinganine + CoA
|
2.3.1.297
very-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS448544
|
|
|
|
hexacosanoyl-CoA + sphinganine <=> CoA + N-cerotoyl-dihydrosphingosine
|
2.3.1.298
ultra-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS449745
|
|
|
|
sphinganine + hexacosanoyl-CoA <=> N-cerotoylsphinganine + CoA
|
2.3.1.297
very-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS448950
|
|
|
|
hexacosanoyl-CoA + sphinganine <=> N-cerotoyl-D-erythro-sphingosine + CoA
|
2.3.1.298
ultra-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS450042
|
|
|
|
sphinganine + arachidoyl-CoA <=> N-arachidoyl-D-sphinganine + CoA
|
2.3.1.297
very-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS448542
|
|
|
|
arachidoyl-CoA + sphinganine <=> CoA + N-arachidoyl-dihydrosphingosine
|
2.3.1.298
ultra-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS449579
|
|
|
|
arachidoyl-CoA + sphinganine <=> N-(arachidoyl)-dihydrosphingosine + CoA
|
2.3.1.299
sphingoid base N-stearoyltransferase
|
–
|
|
|
BRENDA:
BS455325
|
|
|
|
lignoceroyl-CoA + sphinganine <=> 2-hydroxy-lignoceroyl_ceramide + CoA
|
2.3.1.298
ultra-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS450225
|
|
|
|
sphinganine + lignoceroyl-CoA <=> N-lignoceroyl-D-sphinganine + CoA
|
2.3.1.297
very-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS448547
|
|
|
|
lignoceroyl-CoA + sphinganine <=> CoA + N-lignoceroyl-dihydrosphingosine
|
2.3.1.298
ultra-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS450224
|
|
|
|
sphinganine + lignoceroyl-CoA <=> N-lignoceroyldihydrosphingosine + CoA
|
2.3.1.297
very-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS448556
|
|
|
|
behenoyl-CoA + sphinganine <=> a_very-long-chain_sphinganine + CoA
|
2.3.1.297
very-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS454222
|
|
|
|
behenoyl-CoA + sphinganine <=> 2-hydroxy-behenoyl_ceramide + CoA
|
2.3.1.298
ultra-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS449629
|
|
|
|
sphinganine + behenoyl-CoA <=> N-behenoyl-D-sphinganine + CoA
|
2.3.1.297
very-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS448543
|
|
|
|
behenoyl-CoA + sphinganine <=> CoA + N-behenoyl-dihydrosphingosine
|
2.3.1.298
ultra-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS449630
|
|
|
|
sphinganine + behenoyl-CoA <=> N-behenoylsphinganine + CoA
|
2.3.1.297
very-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS448949
|
|
|
|
behenyl-CoA + sphinganine <=> behenyl-sphinganine + CoA
|
2.3.1.297
very-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS455374
|
|
|
|
cerotyl-CoA + sphinganine <=> cerotyl-sphinganine + CoA
|
2.3.1.297
very-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS455456
|
|
|
|
sphinganine + (15Z)-tetracosenoyl-CoA <=> N-nervonoyl-D-sphinganine + CoA
|
2.3.1.297
very-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS448548
|
|
|
|
sphinganine + (15Z)-tetracosenoyl-CoA <=> N-nervonoyldihydrosphingosine + CoA
|
2.3.1.297
very-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS448558
|
|
|
|
sphinganine + (15Z)-tetracosenoyl-CoA <=> N-nervonoylsphinganine + CoA
|
2.3.1.297
very-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS448952
|
|
|
|
(15Z)-tetracosenoyl-CoA + sphinganine <=> CoA + nervonyl-sphinganine
|
2.3.1.297
very-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS456109
|
|
|
|
sphinganine + 2-hydroxystearoyl-CoA <=> N-2-hydroxystearoylsphingosine + CoA
|
2.3.1.299
sphingoid base N-stearoyltransferase
|
–
|
|
|
BRENDA:
BS448555
|
|
|
|
oleoyl-CoA + sphinganine <=> N-(oleoyl)-dihydrosphingosine + CoA
|
2.3.1.299
sphingoid base N-stearoyltransferase
|
–
|
|
|
BRENDA:
BS456134
|
|
|
|
N-arachidonoyl-dihydroceramide + H2O <=> sphinganine + arachidonic_acid
|
3.5.1.23
ceramidase
|
–
|
|
|
BRENDA:
BS414930
|
|
|
|
sphinganine + myristoyl-CoA <=> N-myristoyldihydrosphingosine + CoA
|
2.3.1.24
sphingosine N-acyltransferase
|
–
|
|
|
BRENDA:
BS448557
|
|
|
|
sphinganine + NADH + H+ + O2 <=> phytosphingosine + NAD+ + H2O
|
1.14.18.5
sphingolipid C4-monooxygenase
|
–
|
|
|
BRENDA:
BS433607
|
|
|
|
stearoyl-CoA + sphinganine <=> C18-ceramide + CoA
|
2.3.1.298
ultra-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS450668
|
|
|
|
sphinganine + stearoyl-CoA <=> N-stearoylsphingosine + CoA
|
2.3.1.299
sphingoid base N-stearoyltransferase
|
–
|
|
|
BRENDA:
BS448561
|
|
|
|
stearoyl-CoA + sphinganine <=> ceramide + CoA
|
2.3.1.298
ultra-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS448580
|
|
|
|
sphinganine + stearoyl-CoA <=> C18-ceramide + CoA
|
2.3.1.299
sphingoid base N-stearoyltransferase
|
–
|
|
|
BRENDA:
BS449815
|
|
|
|
stearoyl-CoA + sphinganine <=> CoA + N-stearoyl-dihydrosphingosine
|
2.3.1.298
ultra-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS450669
|
|
|
|
sphinganine + stearoyl-CoA <=> N-stearoyl-DL-dihydrosphingosine + CoA
|
2.3.1.24
sphingosine N-acyltransferase
|
–
|
|
|
BRENDA:
BS450641
|
|
|
|
sphinganine + stearoyl-CoA <=> N-stearoyldihydrosphingosine + CoA
|
2.3.1.24
sphingosine N-acyltransferase
2.3.1.297
very-long-chain ceramide synthase
2.3.1.299
sphingoid base N-stearoyltransferase
|
–
–
–
|
|
|
BRENDA:
BS448560
|
|
|
|
stearoyl-CoA + sphinganine <=> CoA + an_N-acyldihydrosphingosine
|
2.3.1.24
sphingosine N-acyltransferase
|
–
|
|
|
BRENDA:
BS455661
|
|
|
|
stearoyl-CoA + sphinganine <=> N-(stearoyl)-dihydroceramide + CoA
|
2.3.1.299
sphingoid base N-stearoyltransferase
|
–
|
|
|
BRENDA:
BS454651
|
|
|
|
stearoyl-CoA + sphinganine <=> N-(stearoyl)-dihydrosphingosine + CoA
|
2.3.1.299
sphingoid base N-stearoyltransferase
|
–
|
|
|
BRENDA:
BS456687
|
|
|
|
GTP + sphinganine <=> GDP + sphinganine_1-phosphate
|
2.7.1.91
sphingosine kinase
|
–
|
|
|
BRENDA:
BS379834
|
|
|
|
(S)-phospholactate + NADPH + H+ <=> sphinganine + L(-)threo-Sphinganine + NADP+
|
1.1.1.102
3-dehydrosphinganine reductase
|
–
|
|
|
BRENDA:
BS421807
|
|
|
|
(S)-phospholactate + NADPH + H+ <=> sphinganine + NADP+
|
1.1.1.102
3-dehydrosphinganine reductase
|
–
|
|
|
BRENDA:
BS421808
|
|
|
|
2-amino-1-hydroxyoctadecan-3-one + NADPH <=> sphinganine + NADP+
|
1.1.1.102
3-dehydrosphinganine reductase
|
–
|
|
|
BRENDA:
BS186953
|
|
|
|
sphinganine + NADPH + H+ + O2 <=> phytosphingosine + NADP+ + H2O
|
1.14.18.5
sphingolipid C4-monooxygenase
|
–
|
|
|
BRENDA:
BS433608
|
|
|
|
UDP-glucose + sphinganine <=> UDP + D-glucosyl-dihydrosphingosine
|
2.4.1.80
ceramide glucosyltransferase
|
–
|
|
|
BRENDA:
BS322980
|
|
|
|
sphinganine + reduced_acceptor + H+ + O2 <=> phytosphinganine + acceptor + H2O
|
1.14.18.5
sphingolipid C4-monooxygenase
|
–
|
|
|
BRENDA:
BS421518
|
|
|
|
sphinganine + reduced_acceptor + O2 <=> trans-8-sphingenine + acceptor + 2 H2O
|
1.14.19.4
acyl-lipid (11-3)-desaturase
|
–
|
|
|
BRENDA:
BS394993
|
|
|
|
N-stearoylsphinganine + H2O <=> fatty_acid + sphinganine
|
3.5.1.23
ceramidase
|
–
|
|
|
BRENDA:
BS116234
|
|
|
|
sphinganine + behenoyl-CoA <=> N-behenoylsphinganine
|
2.3.1.297
very-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS448948
|
|
|
|
sphinganine + lignoceroyl-CoA <=> N-lignoceroyl-D-sphinganine
|
2.3.1.297
very-long-chain ceramide synthase
|
–
|
|
|
BRENDA:
BS448546
|
|
|
|
sphinganine + palmitoyl-CoA <=> N-palmitoyl-D-sphinganine
|
2.3.1.24
sphingosine N-acyltransferase
|
–
|
|
|
BRENDA:
BS449814
|
|
|
|
sphinganine + Arachidonoyl-CoA <=> N-arachidonoyl-DL-dihydrosphingosine + CoA
|
2.3.1.24
sphingosine N-acyltransferase
|
–
|
|
|
BRENDA:
BS450638
|
|
|
|
sphinganine + ferricytochrome_b5 + O2 + H+ <=> 8-sphingenine + ferricytochrome_b5 + H2O
|
1.14.19.29
sphingolipid 8-(E/Z)-desaturase
|
–
|
|
|
BRENDA:
BS432951
|
|
|
|
N-oleoyl-D-erythro-sphingosine + H2O <=> sphinganine + oleic_acid
|
3.5.1.23
ceramidase
|
–
|
|
|
BRENDA:
BS414986
|
|
|
|
N-octanoylsphinganine + H2O <=> Octanoate + sphinganine
|
3.5.1.23
ceramidase
|
–
|
|
|
SABIO-RK:
10292
|
|